@misc{10498/33879,
year = {2021},
url = {http://hdl.handle.net/10498/33879},
abstract = {To analyze the modifications of CD4 T cell, CD4/CD8 ratio, and serum levels of soluble CD14 (sCD14) in HIV/HCV-coinfected patients after treatment with direct anti-HCV antiviral agents. Consecutive cases of HIV/HCV-coinfected patients, attended at the University Hospital, who achieved sustained virological responses with interferon-free hepatitis C antiviral drugs, were analyzed. Thirty-five percent of patients (n = 39) had been diagnosed with liver cirrhosis. The evaluation criteria were changes in CD4 T-cell counts and percentages and inflammation (measured by serum sCD14 levels) or immune activation indexes (determined by CD4/CD8 ratio) from beginning anti-HCV therapy to 12 months later. One hundred twelve patients were included (87% male; median age, 54 years; median time from the infection diagnosis, 22 years; previous drug users, 87%). Significant increases in CD4 T cell count and percentage were detected only in individuals without liver cirrhosis. No significant differences in CD4/CD8 ratios or sCD14 levels were observed in patients with or without cirrhosis. The proportion of patients with less than 500 CD4 T cell/mm3 before therapy who achieved more than 500 CD4 T cell/mm3 after it increased only in the group without liver cirrhosis. The finding that CD4 T cell count and percentage were improved only in patients without liver cirrhosis supports the idea that treatment against HCV in HIV/HCV-coinfected patients is needed in the early phases of liver disease.},
organization = {Secretaría General de Investigación, Desarrollo e Innovación en Salud, Junta de Andalucía, Iniciativa Territorial Integrada 2014-2020 para la provincia de Cádiz (No PI-0076-2017), Spain. Co-financed by FEDER (Fondo Europeo de Desarrollo Regional).},
publisher = {SPRINGER},
keywords = {HIV infection},
keywords = {Hepatitis C virus},
keywords = {CD4 T cells},
keywords = {CD8 T cells},
keywords = {CD4/CD8 ratio},
keywords = {Soluble CD14},
keywords = {Direct-acting antiviral agents},
keywords = {Sustained viral response},
title = {Modifications of CD4 T cells, CD4/CD8 ratio and serum levels of soluble CD14 in HIV-HCV-coinfected patients after sustained HCV response induced by direct-acting antiviral agents: influence of liver cirrhosis},
doi = {10.1007/s10096-021-04237-y.},
author = {Girón Ortega, José Antonio and Márquez Coello, María de las Mercedes and Gutiérrez Saborido, Daniel and Arizcorreta Yarza, Ana and Cuesta Sancho, Sara and Girón González, José Antonio},
}