@misc{10498/33881,
year = {2019},
url = {http://hdl.handle.net/10498/33881},
abstract = {Analysis of gut barrier status, monocyte and lymphocyte activation and T regulatory (Treg) cells at diagnosis before and after therapy, in patients with multiple sclerosis (MS). Analysis of differential effects of interferon beta (IFN-β), glatiramer acetate (GA) and natalizumab. Thirty-five patients with untreated MS were included. Gut barrier status (serum concentrations of intestinal fatty acid binding protein), monocyte (serum levels of soluble CD14, soluble CD163 and interleukin 6) and T lymphocyte activation (CD4 + DR+ and CD8 + DR+) and Treg (CD4 + CD25highFoxP3+) cells were analyzed. Patients with clinical isolated syndrome and relapsing-remitting forms were treated with IFN-β or GA, and immune characteristics were reevaluated following up after 6 months. A sample of 56 stable RR MS patients, in treatment with IFN-β, GA or natalizumab, and 50 healthy individuals were included as controls. Gut barrier status was similar in MS patients and healthy controls. Untreated patients with relapsing-remitting and primary progressive patterns of MS showed increased serum levels of soluble CD14. At baseline, significant increases in activated T lymphocytes and Treg were detected in patients. A significant decrease of CD4 + DR+, CD8 + DR+, and Treg percentages after 6 months of therapy was observed. In previously treated patients, IFN-β, GA, or natalizumab therapies were associated with a comparable cell proportion of activated lymphocytes and Treg. MS patients have a baseline state characterized by monocyte and lymphocyte activation, not related with gut barrier lesion. An increase in Treg number, correlated with activated T CD8+ lymphocytes, was detected. Treatment with IFN-β, GA or natalizumab was associated with a comparable decrease in activated lymphocytes and Treg.},
organization = {Grant from Neurología, Fundación para la Investigación Biomédica de Cádiz.},
keywords = {Multiple sclerosis},
keywords = {Gut barrier permeability},
keywords = {sCD14},
keywords = {sCD163},
keywords = {Interleukin 6},
keywords = {Activated T lymphocytes},
keywords = {T regulatory cells},
title = {Monocyte and Lymphocyte Activation and Regulation in Multiple Sclerosis Patients. Therapy Effects},
doi = {10.1007/s11481-018-09832-z.},
author = {González-Oria, María del Carmen and Márquez Coello, María de las Mercedes and Girón Ortega, José Antonio and Argente, Joaquín and Moya Molina, Miguel Ángel and Girón González, José Antonio},
}