@misc{10498/34336,
year = {2024},
url = {http://hdl.handle.net/10498/34336},
abstract = {Introduction
This multicenter study aimed to evaluate the Malignant Pleural Effusion Risk (MPER) diagnostic accuracy in distinguishing between benign and malign pleural effusion. Methods: MPER is based on pleural fluid Homocysteine (HCY) and carcinoembryonic antigen (CEA) that were measured using three different methods. MPER was calculated by assessing a previously published probabilistic model: Probability (%) = 100× (1 + e-z)-1, where Z = 0.5471 × [HCY] + 0.3846 × [CEA]–8.2671.
Results
A total of 301 patients were included (140 MPE). MPER demonstrated a high AUC (0.891), sensitivity (84.3 %), and specificity (80.7 %) with a cut-off > 35.3 %.
Conclusions
The MPER model demonstrated a high diagnostic accuracy supporting its use as a novel and powerful tool.Introduction
This multicenter study aimed to evaluate the Malignant Pleural Effusion Risk (MPER) diagnostic accuracy in distinguishing between benign and malign pleural effusion. Methods: MPER is based on pleural fluid Homocysteine (HCY) and carcinoembryonic antigen (CEA) that were measured using three different methods. MPER was calculated by assessing a previously published probabilistic model: Probability (%) = 100× (1 + e-z)-1, where Z = 0.5471 × [HCY] + 0.3846 × [CEA]–8.2671.
Results
A total of 301 patients were included (140 MPE). MPER demonstrated a high AUC (0.891), sensitivity (84.3 %), and specificity (80.7 %) with a cut-off > 35.3 %.
Conclusions
The MPER model demonstrated a high diagnostic accuracy supporting its use as a novel and powerful tool.},
publisher = {Elsevier},
title = {Malignant Pleural Effusion Risk Based On A Novel Tool Using Homocysteine And Carcinoembryonic Antigen In Pleural Fluid: A Multicenter Study},
doi = {10.1016/J.CLINBIOCHEM.2024.110841},
author = {Santotoribio, Jose D. and Corral Pérez, Juan and Nuñez Jurado, David and Fatela Cantillo, Daniel and García de la Torre, Ángela and Orantes Maroto, Gabirel and Del Valle Vázquez, Luis and Del Castillo Otero, Daniel and Maira González, María Nieves and Cobos Diaz, Andrés and Juan M, Guerrero and López Sáez, José Juan Bosco},
}