@misc{10498/34779,
year = {2024},
month = {1},
url = {http://hdl.handle.net/10498/34779},
abstract = {Prenatal infections and cannabis use during adolescence are well-recognized risk factors for schizophrenia. As inflammation and oxidative stress (OS) contribute to this disorder, anti-inflammatory drugs have been proposed as potential therapies. This study aimed to evaluate the association between delta-9-tetrahydrocannabinol (THC) and schizophrenia-like abnormalities in a maternal immune activation (MIA) model. Additionally, we assessed the preventive effect of cannabidiol (CBD), a non-psychotropic/anti-inflammatory cannabinoid. THC and/or CBD were administered to Saline- and MIA-offspring during periadolescence. At adulthood, THC-exposed MIA-offspring showed significant improvements in sensorimotor gating deficits. Structural and metabolic brain changes were evaluated by magnetic resonance imaging, revealing cortical shrinkage in Saline- and enlargement in MIA-offspring after THC-exposure. Additionally, MIA-offspring displayed enlarged ventricles and decreased hippocampus, which were partially reverted by both cannabinoids. CBD prevented THC-induced reduction in the corpus callosum, despite affecting white matter structure. Post-mortem studies revealed detrimental effects of THC, including increased inflammation and oxidative stress. CBD partially reverted these pro-inflammatory alterations and modulated THC's effects on the endocannabinoid system. In conclusion, contrary to expectations, THC exhibited greater behavioural and morphometric benefits, despite promoting a pro-inflammatory state that CBD partially reverted. Further research is needed to elucidate the underlying mechanisms involved in the observed benefits of THC.},
publisher = {Elsevier},
keywords = {cannabidiol},
keywords = {delta-9-tetrahidrocannabino},
keywords = {endocannabinoid system},
keywords = {inflammation},
keywords = {magnetic resonance imaging},
keywords = {oxidative stress},
title = {THC improves behavioural schizophrenia-like deficits that CBD fails to overcome: a comprehensive multilevel approach using the Poly I:C maternal immune activation.},
doi = {10.1016/j.psychres.2023.115643},
author = {Lamanna-Rama, Nicolás and Romero-Miguel, Diego and Casquero-Veiga, Marta and MacDowell, Karina S. and Santa-Marta, C. and Torres Sánchez, Sonia and Berrocoso Domínguez, Esther María and Leza, Juan Carlos and Desco, Manuel and Soto-Montenegro, María Luisa},
}