@misc{10498/34948,
year = {2009},
month = {6},
url = {http://hdl.handle.net/10498/34948},
abstract = {A prospective study of 37 patients with pSS and 20 healthy controls was performed to analyze the differences in circulating levels of macrophage-derived and Th1/Th2 cytokines which could explain the hyperimmunoglobulinemia, characteristic of primary Sjögren’s syndrome (pSS). Serum levels of interleukin (IL)-6, IL-10, IL-12, gamma-interferon (γ-INF) and IL-4 were analyzed by a sandwich immunoassay-based protein array system. When compared with the control group, higher levels of IL-6, IL-12 and IL-10 and a lower Th1/Th2 ratio, as demonstrated by the γ-INF/IL-4 ratio, were detected in patients. The levels of IL-4 were notably higher in pSS patients with monoclonal gammopathy. Serum IL-4 and IL-10 levels and immunoglobulin G concentrations were significantly correlated. In conclusion, patients with pSS show a state of macrophage and T-lymphocyte activation with increased concentrations of cytokines implicated in the differentiation of B cells and secretion of immunoglobulins.},
publisher = {Elsevier},
title = {Implications of immunomodulatory interleukins for the hyperimmunoglobulinemia of Sjögren's syndrome},
doi = {10.1016/J.CELLIMM.2009.05.013},
author = {Girón González, José Antonio and Baturone, Rocio and Soto, Maria José and Márquez Coello, María de las Mercedes and Macias, Inmaculada and Montes de Oca, Montserrat and Medina, Fermín and Chozas Candanedo, Nicolás and García-Perez, S},
}