@misc{10498/35068,
year = {2015},
url = {http://hdl.handle.net/10498/35068},
abstract = {Placental metabolism is an important mechanism for the regulation of fetal growth and long-term health of the newborns. In this study, we investigated the effects of maternal metabolic environment on human placental fatty acid and glucose metabolism. We used placental explants from uncomplicated pregnancies or pregnancies complicated with gestational diabetes mellitus (GDM), undergoing
vaginal delivery (VD) or cesarean section (CS). Fatty acid oxidation (FAO) and glucose uptake (2-DOG) were similar in both modes of delivery in normal and GDM pregnancies. However, placental explants from GDM exhibited 40% to 50% reduced FAO capacity compared to control placentas in women undergoing VD or CS. In contrast, 2-DOG uptake was 2- to 3-fold higher in placental explants from GDM compared to control placentas in women undergoing VD or CS, respectively. In conclusion, ex vivo placental fuel selection is influenced by maternal GDM, but placental metabolic characteristics are not altered by the mode of delivery.},
publisher = {SAGE PUBLICATIONS INC/ SPRINGER HEIDELBERG},
keywords = {fatty acid oxidation},
keywords = {glucose uptake},
keywords = {gestational diabetes mellitus},
keywords = {placental villous explants},
title = {Glucose and Fatty Acid Metabolism in Placental Explants From Pregnancies Complicated With Gestational Diabetes Mellitus},
doi = {10.1177/1933719114561558},
author = {Visiedo García, Francisco Manuel and Bugatto González, Fernando and Quintero Prado, Rocío and Cózar Castellano, Irene and Bartha Rasero, Jose luis and Perdomo Hernandez, German},
}