@misc{10498/35229,
year = {2017},
month = {11},
url = {http://hdl.handle.net/10498/35229},
abstract = {The chemical study of the bryozoan Schizomavella mamillata has led to the isolation of six new 5-alkylresorcinol derivatives, schizols A–F (1–6), whose structures were established by spectrocospic means. Schizol A (1) exhibits a (E)-6-phenylnon-5-enyl moiety linked to the C-5 of a resorcinol ring, while in schizol B (2) the substituent at C-5 contains an unusual 1,2-dihydrocyclobutabenzene moiety. Schizols C (3) and D (4) have been characterized as the 1-sulfate derivatives of 1 and 2, respectively, and schizols E (5) and F (6) are the corresponding 1,3-disulfates. Schizol A (1) has been synthetized from 3,5-dimethoxybenzaldehyde through a sequence involving a Wittig reaction for the construction of the C-10,C-20 bond and a Julia–Kocienski olefination for the synthesis of the C-50,C-60 double bond. In the ABTS (2,20-azinobis(3-ethylbenzothiazoline-6-sulphonic acid)) antioxidant assay, the natural compounds schizol A (1) and schizol B (2) showed higher radical scavenging activity than the Trolox standard.},
publisher = {MDPI},
keywords = {alkylresorcinols},
keywords = {bryozoans},
keywords = {Schizomavella},
keywords = {1,2-dihydrocyclobutabenzene},
keywords = {olefination},
keywords = {antioxidant},
title = {5-Alkylresorcinol Derivatives from the Bryozoan Schizomavella mamillata: Isolation, Synthesis, and Antioxidant Activity},
doi = {10.3390/MD15110344},
author = {Ortega Agüera, María Jesús and Pantoja, Juan José and Reyes Jiménez, Carolina de los and Zubía Mendoza, Eva},
}