@misc{10498/35863,
year = {2023},
url = {http://hdl.handle.net/10498/35863},
abstract = {Introduction: Infections caused by carbapenem-resistant Enterobacterales (CRE) and carbapenem-resistant Pseudomonas aeruginosa, including isolates producing acquired carbapenemases, constitute a prevalent health problem worldwide. The primary objective of this study was to determine the distribution of the different carbapenemases among carbapenemase-producing Enterobacterales (CPE, specifically Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae complex, and Klebsiella aerogenes) and carbapenemase-producing P. aeruginosa (CPPA) in Spain from January 2014 to December 2018. Methods: A national, retrospective, cross-sectional multicenter study was performed. The study included the first isolate per patient and year obtained from clinical samples and obtained for diagnosis of infection in hospitalized patients. A structured questionnaire was completed by the participating centers using the REDCap platform, and results were analyzed using IBM SPSS Statistics 29.0.0. Results: A total of 2,704 carbapenemase-producing microorganisms were included, for which the type of carbapenemase was determined in 2692 cases: 2280 CPE (84.7%) and 412 CPPA (15.3%), most often using molecular methods and immunochromatographic assays. Globally, the most frequent types of carbapenemase in Enterobacterales and P. aeruginosa were OXA-48-like, alone or in combination with other enzymes (1,523 cases, 66.8%) and VIM (365 cases, 88.6%), respectively. Among Enterobacterales, carbapenemase-producing K. pneumoniae was reported in 1821 cases (79.9%), followed by E. cloacae complex in 334 cases (14.6%). In Enterobacterales, KPC is mainly present in the South and South-East regions of Spain and OXA-48-like in the rest of the country. Regarding P. aeruginosa, VIM is widely distributed all over the country. Globally, an increasing percentage of OXA-48-like enzymes was observed from 2014 to 2017. KPC enzymes were more frequent in 2017–2018 compared to 2014–2016. Discussion: Data from this study help to understand the situation and evolution of the main species of CPE and CPPA in Spain, with practical implications for control and optimal treatment of infections caused by these multi-drug resistant organisms.},
publisher = {Frontiers Media SA},
keywords = {Klebsiella pneumoniae},
keywords = {Escherichia coli},
keywords = {Enterobacter cloacae complex},
keywords = {Klebsiella (Enterobacter) aerogenes},
keywords = {Pseudomonas aeruginosa},
keywords = {carbapenemases},
keywords = {geographical distribution},
title = {The CARBA-MAP study: national mapping of carbapenemases in Spain (2014–2018)},
doi = {10.3389/FMICB.2023.1247804},
author = {Gracia Ahufinger, Irene and López González, Laura and Vasallo, Francisco José and Galar, Alicia and Siller, María and Pitart, C. and Bloise, I. and Torrecillas, Miriam and Gijón-Cordero, Desireé and Viñado, Belén and Castillo-García, Javier and Campo, Rainer and Mulet, Xavier and Madueño-Alonso, Ana and Chamizo-López, Francisco Javier and Arrastia-Erviti, Maitane and Galán Sánchez, Fátima and Fernández-Quejo, Melisa and Rodríguez-Díaz, Juan Carlos and Gutiérrez-Zufiaurre, María Nieves and Rodríguez-Maresca, Manuel Ángel and Ortega-Lafont, María del Pilar and Yagüe-Guirao, Genoveva and Chaves-Blanco, Lucía and Chaves-Blanco, Javier and Colomina-Rodríguez, Javier and Vidal-Acuña, María Reyes and Portillo, María Eugenia and Franco-Álvarez de Luna, Francisco and Centelles-Serrano, M.J. and Azcona-Gutiérrez, José Manuel and Delgado-Iribarren García Campero, Alberto and Rey-Cao, Sonia and Muñoz, Patricia and Calvo-Montes, Jorge and Zboromyrska, Yuliya and Grandioso, David and Cámara, Jordi and Cantón, Rafael and Larrosa-Escartín, Nieves and Díaz-Regañón, Jazmín and Martínez-Martínez, Luis},
}