@misc{10498/36918,
year = {2025},
month = {3},
url = {http://hdl.handle.net/10498/36918},
abstract = {Sponges of the genus Neopetrosia are known for the
production of a large diversity of bioactive metabolites.
Contignasterines A (1) and B (2) were isolated as major
metabolites of the sponge Neopetrosia cf. rava collected in the
Bismarck Sea along with the known and highly bioactive steroid
contignasterol (3) possessing a similar oxidized aglycone.
Contignasterines are characterized by the presence of a 2-
aminoimidazole branched on the side-chains of the oxidized
steroid, and 1 also contains an unusual phosphate group at C-7.
The anti-inflammatory activities of these compounds were
investigated and revealed that all three compounds inhibited the
production of pro-inflammatory mediators},
publisher = {ACS Publications},
title = {Contignasterines, Anti-Inflammatory 2-Aminoimidazole Steroids from the Sponge Neopetrosia cf. rava Collected in the Bismarck Sea},
doi = {10.1021/acs.jnatprod.5c00118},
author = {Ortega-Vidal, J. and Reddy, M. M. and Pérez-Fuentes, N. and Alvariño, R. and Burth, S. and Alfonso, A. and Vale, C. and Roca Virués de Segovia, Jorge and Mungkaje, A. and Botana, L. M. and Thomas, O. P.},
}