@misc{10498/36978,
year = {2025},
url = {http://hdl.handle.net/10498/36978},
abstract = {Background The relative contribution of the diferent components of mechanical power to mortality is a subject
of debate and has not been studied in COVID-19. The aim of this study is to evaluate both the total and the rela‑
tive impact of each of the components of mechanical power on mortality in a well-characterized cohort of patients
with COVID-19-induced acute respiratory failure undergoing invasive mechanical ventilation. This is a secondary
analysis of the CIBERESUCICOVID project, a multicenter observational cohort study including ffty Spanish intensive
care units that included COVID-19 mechanically ventilated patients between February 2020 and December 2021. We
examined the association between mechanical power and its components (elastic static, elastic dynamic, total elastic
and resistive power) with 90-day mortality after adjusting for confounders in seven hundred ninety-nine patients
with COVID-19-induced respiratory failure undergoing invasive mechanical ventilation.
Results At the initiation of mechanical ventilation, the PaO2/FiO2 ratio was 106 (78; 150), ventilatory ratio was 1.69
(1.40; 2.05), and respiratory system compliance was 35.7 (29.2; 44.5) ml/cmH2O. Mechanical power at the initiation
of mechanical ventilation was 24.3 (18.9; 29.6) J/min, showing no signifcant changes after three days. In multivariable
regression analyses, mechanical power and its components were not associated with 90-day mortality at the start
of mechanical ventilation. After three days, total elastic and elastic static power were associated with higher 90-day
mortality, but this relationship was also found for positive end-expiratory pressure Conclusions Neither mechanical power nor its components were independently associated with mortality in COVID19-induced acute respiratory failure at the start of MV. Nevertheless, after three days, static elastic power and total
elastic power were associated with lower odds of survival. Positive end-expiratory pressure and plateau pressure,
however, captured this risk in a similar manner.},
publisher = {Springer Nature},
keywords = {Mechanical power},
keywords = {COVID-19},
keywords = {Mechanical ventilation},
keywords = {Respiratory failure},
title = {Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patients},
doi = {10.1186/s13613-025-01430-6},
author = {Barbeta, Enric and Barreiros, Cláudia and Forin, Edoardo and Guzzardella, Amedeo and Motos, Anna and Fernández Barat, Laia and Gabarrús, Albert and Ceccato, Adrián and Ferrer, Ricard and Riera, Jordi and Peñuelas, Oscar and Lorente, José A. and de Gonzalo Calvo, David and González, Jessica and Amaya Villar, Rosario and Añón, José Manuel and Balan, Ana and Barberà, Carme and Barberán, José and Blandino, Aaron and Boado, María Victoria and Bustamante Munguira, Elena and Caballero, Jesús and Cantón-Bulnes, Luisa and Carbajales, Cristina and Carbonell, Nieves and Catalán‑González, Mercedes and Franco, Nieves and Galban, Cristóbal and Gumucio-Sanguino, Víctor D. and de la Torre, María del Carmen and Díaz, Emilio and Estella García, Ángel and Gallego, Elena and Gómez, José Manuel and Huerta, Arturo and Jorge García, Ruth Noemí and Loza Vázquez, Ana and Marin Corral, Judith and Martín Delgado, María Cruz and Martínez, Amalia and Martínez, Ignacio and López, Juan and Albaiceta, Guillermo M. and Nieto, María Teresa and Andrea Novo, Mariana and Peñasco, Yhivian and Pérez García, Felipe and Ricart, Pilar and Rodríguez, Alejandro and Sagredo, Víctor and Sánchez Miralles, Ángel and Sancho, Susana and Roche-Campo, Ferran and Socias, Lorenzo and Solé Violán, Jordi and Tamayo, Luis and Trenado, José and Úbeda, Alejandro and Valdivia, Luis Jorge and Vidal, Pablo and Barbé, Ferrán and Vallverdú, Jordi and Torres, Antoni and CIBERESUCICOVID Project investigators (COV20/00110, ISCIII)},
}