@misc{10498/38038,
year = {2025},
month = {5},
url = {http://hdl.handle.net/10498/38038},
abstract = {Background: After sustained virological response (SVR), liver stiffness (LS) usually decreases. However, information related to the impact of HIV co-infection in patients with advanced fibrosis is scarce. The aim was to analyze the impact of HIV co-infection on the LS dynamics after HCV cure. Methods: Prospective study conducted in the GEHEP-011 multicenter cohort (initiated in October 2011–November 2023, ID NCT04460157), including patients with chronic HCV infection, with or without HIV co-infection, fulfilling: 1) SVR with direct-acting antivirals; 2) pre-treatment LS ≥ 9.5 kPa; 3) available measurement of LS at SVR. Pre-treatment, SVR and annual post-treatment LS were assessed. The primary outcome was time to LS normalization achievement (≤7.2 kPa) in two consecutive examinations. Findings: 1138 patients were included, 678 (60%) of whom were living with HIV (PLWH). The median time between the first to the last measure was 35 (17–69) months. In total, 390 [34% (95% confidence interval, 31%–37%)] patients achieved LS normalization, 169 [37% (CI 95%, 34%–43%)] individuals with HCV mono-infection vs. 221 [32% (CI 95%, 29%–36%)] PLWH achieved LS normalization (p = 0.003). The propensity score (PS) for HIV infection was calculated. In a multivariate model for competing risks (death was the competing event) adjusted for HIV, PS and diabetes, HIV infection was associated with a lower probability of achieving normalization [sHR = 0.82 (95% CI, 0.67–1.00), p = 0.045]. Matching by closer PS was performed. In the resultant subset, the probability of achieving LS normalization was again lower in PLWH [sHR = 0.76 (0.56–0.97), p < 0.001]. Interpretation: After SVR, the probability of reaching LS normalization is significantly lower in PLWH. This could have implications on the development of long-term clinical events. Funding: Project PI19/01443, ERDF/ESF “Investing in your future”, GLD21_00096, GEHEP-011 project, B-0061-2021, JR24/00044, A1-0060-2021, CM23/00255, CM22/00176.},
publisher = {Public Library of Science},
keywords = {HIV},
keywords = {Hepatitis C},
keywords = {Sustained viral response},
keywords = {Transient elastography},
keywords = {Liver stiffness},
title = {Impact of HIV infection on the dynamics of liver stiffness in patients with hepatitis C virus chronic infection after sustained virological response},
doi = {10.1016/J.ECLINM.2025.103227},
author = {Martín Carmona, Jésica and Corma Gómez, Anaïs and Moyano, Jose M. and Téllez Pérez, Francisco de Paula and Arenga Barrios, Dolores and Serrano-Fuentes, Miriam and Morano Vázquez, Aitana Carla and Corona Mata, Diana and Navarrete Lorite, Miguel Nicolás and Vera-Méndez, Francisco Jesús and Barroso, Isabel and Palacios, Rosario and de los Santos, Ignacio and Belinchón, Olga and Galera, Carlos and Imaz, Arkaitz and Merino, Dolores and Reus Bañuls, Sergio Javier and Galindo, Maria Jose and López-Zuñiga, Miguel Ángel and Pineda, Juan A. and Macías, Juan},
}