@misc{10498/38300,
year = {2025},
month = {12},
url = {http://hdl.handle.net/10498/38300},
abstract = {Novel Thiol-functionalized tungsten iron oxide nanoparticles with potential applications as contrast agents in medical imaging have been obtained using scanning pulsed ablation in liquid. First, bulk ceramic targets of an orthorhombic (Pbcn) iron (III) tungstate phase type γ-Fe2WO6 with a tri-a-PbO2 structure were prepared using a reaction-sintering method. Then, colloidal dispersions of nanoparticles were produced directly in both distilled water and ethanol by irradiating bulk γ-Fe2WO6 targets with high-power infrared nanosecond laser pulses. In addition, ex situ functionalization processes using glutathione or cysteamine as capping agents were applied, to enhance biocompatibility and colloidal stability at physiological pH values. A battery of techniques was used to characterize the γ-Fe2WO6 targets, the as-synthesized and the functionalized colloidal dispersions of W/Fe nanoparticles, including their composition, structure, magnetic properties, X-ray attenuation potential, biocompatibility and colloidal properties. The results indicate the successful formation of amorphous W/Fe nanoparticles using both distilled water or ethanol as the ablation medium, although only those synthesized in ethanol display a dominant ferromagnetic behavior, making them suitable for use as contrast agents in MRI. Moreover, nanoparticle colloidal dispersions synthesized in ethanol exhibit high X-ray attenuation. The linkage mechanism of functionalization was extensively studied to obtain information for subsequent bioconjugation. The formation of NPs with higher stability and proper functionalization occurs when cysteamine was used as a capping agent, although biocompatibility is better when using glutathione. Finally, functionalized W/Fe nanoparticles demonstrated good magnetic resonance imaging and X-ray computerized tomography imaging abilities, suggesting promising potential as dual-contrast agents.},
organization = {Spanish Ministry of Economy and Competitiveness (MINECO) and FEDER [research projects MAT2015-67354R].
H2020 Action H2020-MSCA-IF-2014_ST [grant 656908-NIMBLIS] of the Executive Agency for Research Manages of EU Commission, 
IMEYMAT-UCA. Proyectos Integradores MdM-IMEYMAT 2020 call (research project ULST-NANO).
Spanish MCIN/AEI/10.13039/501100011033/FEDER (project PID2020-118329RB-I00) and MICIU/AEI/10.13039/501100011033/FEDER (project PID2023-150767OB-I00).
Consejería Salud y Familias. Junta de Andalucía. Project PECART-0096-2020.
Consejería Economía, Conocimiento, Empresas y Universidad. Junta de Andalucia. Project P20_01293.},
publisher = {Elsevier B.V},
title = {Pulsed laser ablation synthesis of thiol-functionalized W/Fe nanoparticles in liquid for MRI and CT imaging},
doi = {10.1016/j.ceramint.2025.11.127},
author = {Félix Ruiz, Eduardo José and Litrán Ramos, Rocío and Manuel Delgado, José Manuel and Rodríguez, Miguel Ángel and Fernández Ponce, Cecilia Matilde and García-Cozar, FJ and Yeste Siguenza, María del Pilar and Lahoz, Ruth and Natividad, Eva and García Villar, Cristina and Llaguno-Munive, Montserrat and Abasolo, Ibane and Pfaff, C and Kriwet, J and Bomati Miguel, Óscar},
}