@misc{10498/39158,
year = {2025},
url = {http://hdl.handle.net/10498/39158},
abstract = {A novel methodology for the direct gem-dimethylcyclopropanation of a series of acyclic and cyclic primary and secondary allylic alcohols is herein described. The reaction proceeds in a regio-, chemo-, and stereoselective manner, affording the corresponding gem-dimethylcyclopropane derivatives in moderate yields. We postulate that an alkylidene titanocene, generated in situ from sub-stoichiometric amounts of low-valent titanium species, Mg and 2,2-dichloropropane under mild reaction conditions, serves as the active species. The scope, limitations and a plausible mechanism of this metal-promoted transformation are also presented.},
publisher = {Wiley},
keywords = {Carbenoids},
keywords = {Chemoselectivity},
keywords = {CpTiCl3},
keywords = {Gem-dimethylcyclopropanation},
keywords = {Titanocene},
title = {Highly Stereoselective Gem-Dimethylcyclopropanation of Allylic Alcohols Promoted by Alkylidene Titanocenes},
doi = {10.1002/AJOC.202500606},
author = {Botubol Ares, José Manuel and Castillo Ruiz, Natalia and González Collado, Isidro and Durán Peña, María Jesús and Hernández Galán, Rosario},
}