@misc{10498/39207,
year = {2008},
month = {10},
url = {http://hdl.handle.net/10498/39207},
abstract = {Anti-TNF agents are increasingly being used for a rapidly expanding number of rheumatic and systemic autoimmune diseases. As a result of this use, and of the longer follow-up periods of treatment, there are a growing number of reports of the development of autoimmune processes related to anti-TNF agents. The clinical characteristics, outcomes, and patterns of association with the different anti-TNF agents used in all reports of autoimmune diseases developing after TNF-targeted therapy, were analyzed through a baseline Medline search of articles published between January 1990 and May 2008 (www.biogeas.org). A total of 379 cases of autoimmune diseases secondary to TNF-targeted therapies were identified. The anti-TNF agents were administered for rheumatoid arthritis in more than 80% of cases. The use of anti-TNF agents has been associated with an increasing number of cases of autoimmune diseases, principally cutaneous vasculitis, lupus-like syndrome, systemic lupus erythematosus and interstitial lung disease. Other autoimmune diseases associated with TNF-targeted therapies have been recently described, e.g. sarcoidosis, antiphospholipid syndrome-related features, and autoimmune hepatitis or uveitis. Large, prospective, postmarketing studies are required to evaluate the risk of developing autoimmune diseases in patients receiving TNF-targeted therapies.},
publisher = {Elsevier},
keywords = {adalimumab},
keywords = {anti-TNF},
keywords = {etanercept},
keywords = {infliximab},
keywords = {interstitial lung disease},
keywords = {lupus},
keywords = {thrombosis},
keywords = {vasculitis},
title = {Autoimmune diseases induced by TNF-targeted therapies},
doi = {10.1016/j.berh.2008.09.008},
author = {Ramos Casals, Manuel and Brito Zerón, Pilar and Soto Cardenas, María José and Cuadrado, Maria Jose and Khamastha, Munther A.},
}