@misc{10498/39311,
year = {2025},
url = {http://hdl.handle.net/10498/39311},
abstract = {There is an increasing interest in the use of biopesticides, which implies the use of living microorganisms, plant and
microbial extracts, and natural products isolated from the above-mentioned sources or closely related derivatives. In this regard, 10
farnesyloxy-arenes derivatives (21−25, (±)-26−(±)-30) and 12 drimanyloxyarenes derivatives ((±)-12−(±)-14, (±)-31−(±)-40)
were synthesized and tested against the phytopathogenic fungus Botrytis cinerea. In general, the drimanyloxyarenes derivatives were
more fungitoxic than their farnesyloxyarene precursors. The most active compounds were (±)-12, (±)-31, and (±)-35, which at a
391 × 10−5 mg/mL dose, were more active than azoxystrobin, while (±)-12 presented an inhibition comparable to that of triclosan.
Structure−activity relationships are discussed, as well as the correlation with calculated physicochemical properties such as logP and
total polar surface area.},
publisher = {American Chemical Society},
keywords = {Botrytis cinerea},
keywords = {phytopathogenic fung},
keywords = {antifungal},
keywords = {hybrid molecules},
keywords = {farnesyloxyarenes},
keywords = {drimanyloxyarenes},
title = {Synthesis of Farnesyloxy- and Drimanyloxy-Arene Scaffold-Based Hybrid Molecules as Antifungals against Botrytis cinerea},
doi = {10.1021/ACS.JAFC.5C06584},
author = {Ruano González, Antonio and Pinto, Ana Andreina and Mancilla, Gabriela and Sánchez Maestre, Rosario and Aleu, Josefina and Hernández Galán, Rosario and Macías Sánchez, Antonio José and González Collado, Isidro},
}