@misc{10498/39684,
year = {2018},
month = {3},
url = {http://hdl.handle.net/10498/39684},
abstract = {Methylation of the secondary amine groups of a scorpiand-type ligand consisting of a pyridine spacer connected through methylene groups to a tris(2-aminomethyl) unit with the pendant arm further functionalised with a 3-pyridine unit leads to a ligand whose Cu(II) complex exhibits three-fold enhanced SOD activity with respect to the non-methylated ligand. Potentiometric studies indicate the formation of [CuL]2+ species with a stability three orders of magnitude lower than that formed with the related non-methylated ligand. Kinetic studies indicate that methylation of the secondary nitrogens causes a deceleration of both the complex formation and the acid-induced dissociation of the metal ion. The reduction in stability associated to the poorer -donor ability of the tertiary amino groups shifts the Cu(II)/Cu(I) redox potentials towards more positive values permitting a better cycling between both states needed for the dismutation of superoxide radicals.},
publisher = {Elsevier},
keywords = {SOD activity},
keywords = {Kinetics},
keywords = {Copper complexes},
keywords = {Scorpiand-like azamacrocycles},
title = {Methylation as an Effective Way to Generate SOD-Activity in Copper Complexes of Scorpiand-Like Azamacrocyclic Receptors},
doi = {10.1016/j.ica.2017.08.044},
author = {Nebot-Guinot, Aida and Liberato González, Andrea and Máñez Muñoz, María Ángeles and Clares, M. Paz and Doménech-Carbó, Antonio and Pitarch-Jarque, Javier and García Basallote, Manuel and García España, Enrique},
}