@misc{10498/40391,
year = {2026},
month = {9},
url = {http://hdl.handle.net/10498/40391},
abstract = {Resting-state eye conditions modulate cortical oscillations, but their impact on subthalamic nucleus (STN) and cortico-STN dynamics in Parkinson's disease (PD) remains poorly understood. Here, we characterized electrophysiological changes in the STN and cortical interactions during eyes-open (EO) and eyes-closed (EC) conditions in 12 PD patients undergoing deep brain stimulation surgery. Spontaneous local field potentials in the STN (STN-LFP) and surface electroencephalogram (EEG) activity were simultaneously obtained on postoperative days 2-3 in the OFF-medication state. Power spectral density (PSD), coherence (COH), and Granger causality measures between STN-LFPs and frontal-occipital cortical areas were analyzed. These metrics revealed significant EO-EC differences, particularly in the low-frequency (LF, 4-12[Formula: see text]Hz) range. Although LF power increased across all regions during EC relative to EO, only STN and frontal EEG showed statistically significant changes. EC elicited increased frontal-STN COH within both the LF and low-beta bands (13-21[Formula: see text]Hz), accompanied by enhanced occipital-STN coupling in the low-beta range. In contrast, the influence of the alpha-band frontal cortex on the STN was more pronounced during EO. These findings confirm that eye states may differentially modulate functional connectivity through widespread cortical and STN-cortical interactions and suggest that, in unmedicated PD, EC and EO dynamically modulate large-scale cortical-STN network activity.},
publisher = {World Scientific, Vol. 36, No. 9 (2026) 2650031 (20 pages)},
keywords = {Local  field potentials (LFPs)},
keywords = {electroencephalography (EEG)},
keywords = {resting state},
keywords = {functional connectivity},
keywords = {Parkinson's disease (PD)},
keywords = {deep brain stimulation (DBS)},
title = {Cortical-Subthalamic Interplay During Eyes-Open and Eyes-Closed Resting States in Parkinson's Disease Patients},
doi = {10.1142/S0129065726500310},
author = {Sanmartino, Florencia Soledad and Rashid Abdu Rahim López, Raúl and López Sosa, Fernando and Cruz Gómez, Álvaro Javier and Lozano Soto, Elena María and Rique Dormido, Jesús and Espinosa Rosso, Raúl and González Rosa, Javier Jesús},
}