%0 Journal Article 
%A Pinedo Rivilla, Cristina
%A Aleu Casatejada, Josefina
%A Grande Benito, Manuel
%A González Collado, Isidro
%T Biocatalytic preparation and absolute configuration of enantiomerically pure fungistatic anti-2-benzylindane derivatives. Study of the detoxification mechanism by Botrytis cinerea
%D 2010
%U http://hdl.handle.net/10498/17360
%X Enantiomerically pure 2-benzylindane derivatives were prepared using biocatalytic methods and their
absolute configuration determined. (1R,2S)-2-Benzylindan-1-ol ((1R,2S)-2) and
(S)-2-benzylindan-1-one ((S)-3) were produced by fermenting baker’s yeast. Lipase-mediated
esterifications and hydrolysis of the corresponding racemic substrates gave rise to the enantiopure
compounds (1S,2R)-2-benzylindan-1-ol ((1S,2R)-2) and (1R,2S)-2-benzylindan-1-ol ((1R,2S)-2),
respectively. The antifungal activity of these products against two strains of the plant pathogen Botrytis
cinerea was tested. The metabolism of anti-(±)-2-benzylindan-1-ol (anti-(±)-2) by B. cinerea as part of
the fungal detoxification mechanism is also described and revealed interesting differences in the genome
of both strains.
%K anti-2-benzylindane
%K Biocatalytic
%K Botrytis cinerea
%~ Universidad de Cádiz