%0 Journal Article 
%A Oliveros-Bastidas, Alberto
%A Chinchilla Salcedo, Nuria
%A Marín Sánchez, David
%A González Molinillo, José María
%A Macías Domínguez, Francisco Antonio
%T Soil biodegradation of a benzoxazinone analog proposed as a natural products-based herbicide
%D 2015
%U http://hdl.handle.net/10498/20318
%X Aims Benzoxazinones with the 4-hydroxy-(2H)-1,4- benzoxazin-3(4H)-one skeleton have been proposed as potentially successful models for the development of novel design leads. D-DIBOA has proven to be the most promising base structure in the search for novel herbicide models based on the benzoxazinone skeleton. The
biodegradation dynamics of D-DIBOA in soil are therefore relevant and are the subject of this study. Methods A previously optimized methodology for the assessment of biodegradation has been applied for the first time to a synthetic benzoxazinone. Results Biodegradability is a characteristic of natural benzoxazinones and a safety requirement for the development of herbicidal chemicals. The biodegradation phenomenon and its consequences for the development of new herbicide models are discussed. The half-life determined for D-DIBOA was much higher than those previously reported for the natural products DIBOA, DIMBOA and their benzoxazolinone derivatives. Conclusions This finding, together with its previously described potent phytotoxicity, suggests that D-DIBOA is a useful candidate for novel herbicide model development. The lactam D-HBOA, which is slightly less phytotoxic than its precursor, was discovered to be the first and principal metabolite resulting from D-DIBOA degradation.
%K D-DIBOA
%K benzoxazinones
%K degradation study
%K soil
%K herbicide models
%~ Universidad de Cádiz