%0 Journal Article 
%A Marín Barrios, Rubén
%A Guerra, Francisco M.
%A García-Cabeza, Ana Leticia
%A Moreno Dorado, Francisco Javier
%A Martínez Massanet, Guillermo
%T Multivariate optimization of the KharascheSosnovsky allylic oxidation of olefins
%D 2012
%U http://hdl.handle.net/10498/20503
%X The multivariate optimization method known as simplex is applied to the KharascheSosnovsky allylic oxidation of double bonds. By applying this method, the amounts of three variables (copper source, oxidant, and additive) are optimized at the same time. Under the conditions thus obtained the reaction takes place in a considerable shorter time, being the alkene the limiting reagent. These conditions are applied to some monoterpenes and sesquiterpenes leading regioselectively to the corresponding benzoate esters, opening a route to the employment of this reaction in the synthesis of more complex molecules.
%K allylic oxidation
%K olefins
%K kharasch-sosnovsky reaction
%K simplex
%K multivariate optimization
%~ Universidad de Cádiz