%0 Journal Article 
%A Botubol Ares, José Manuel
%A Macías Sánchez, Antonio José
%A González Collado, Isidro
%A Hernández Galán, Rosario
%T Stereoselective Synthesis and Absolute Configuration Determination of Xylariolide A
%D 2013
%U http://hdl.handle.net/10498/20572
%X The asymmetric synthesis of the antibacterial and antitumoral natural compound xylariolide A (1) and five stereoisomers has been achieved. The strategy is based on the onepot epoxidation/lactonisation or dihydroxylation/lactonisation of the hypothetical biosynthetic intermediate xylarioic A acid (8). The absolute configuration of xylariolide A was thus determined to be 3R,4S,5R,1 R,2 R after the synthesis of 1, two epimers, i.e., 1 -epi-xylariolide A (3) and 2 -epi-xylariolide A (4), and three more diastereoisomers 5–7.
%K Natural products
%K Total synthesis
%K Asymmetric synthesis
%K Configuration determination
%K Medicinal chemistry
%K Lactones
%~ Universidad de Cádiz