%0 Journal Article 
%A Botubol Ares, José Manuel
%A Durán Peña, María Jesús
%A Macías Sánchez, Antonio José
%A Hanson, J. R.
%A González Collado, Isidro
%A Hernández Galán, Rosario
%T Exploring mutasynthesis to increase structural diversity in the synthesis of highly oxygenated polyketide lactones
%D 2014
%U http://hdl.handle.net/10498/20576
%X The enantioselective synthesis of (2R,3R,4E,8E)-3-hydroxy-2,4,8-trimethyldeca-4,8-dienolide (5) by
ring-closing metathesis is described. This compound is an analogue of 3,4-dihydroxy-2,4,6,8-tetramethyldec-
8-enolide (4) which is a rare 11-membered lactone produced by the fungus, Botrytis cinerea.
Mutasynthetic studies with compound 5 using two mutants of B. cinerea led to the isolation of four new
highly oxygenated 11-membered lactones (11–14) in which compound 5 has been stereoselectively
epoxidized and hydroxylated at sites that were not easily accessible by classical synthetic chemistry.
%~ Universidad de Cádiz