%0 Journal Article 
%A Botubol Ares, José Manuel
%A Durán Peña, María Jesús
%A Macías Sánchez, Antonio José
%A R. Hanson, James
%A González Collado, Isidro
%A Hernández Galán, Rosario
%T The Asymmetric Total Synthesis of Cinbotolide: A Revision of the Original Structure
%D 2014
%U http://hdl.handle.net/10498/20578
%X The structure 3,4-dihydroxy-2,4,6,8-tetramethyldec-8-enolide (1) was assigned to a metabolite of Botrytis cinerea, but the spectra of several synthetic analogues had significant differences from that of 1. Examination of the constituents of a B. cinerea mutant that overproduces polyketides gave sufficient quantities of 1, now named cinbotolide, for chemical transformations. These led to a revised γ-butyrolactone structure for the metabolite. This structure has been confirmed by an asymmetric total synthesis, which also established its absolute configuration.
%~ Universidad de Cádiz