%0 Journal Article 
%A Botubol Ares, José Manuel
%A Durán Peña, María Jesús
%A Hernández Galán, Rosario
%A González Collado, Isidro
%A M. Harwood, Laurence
%A Macías Sánchez, Antonio José
%T Diastereoselective and enantioselective preparation of nor-mevaldic acid surrogates through desymmetrisation methodology. Enantioselective synthesis of (+) and (-) nor-mevalonic lactones
%D 2015
%U http://hdl.handle.net/10498/20582
%X Solvent-free desymmetrisation of a meso-dialdehyde with chiral alcohols, led to preparation of 4- silyloxy-6-alkyloxytetrahydro-2H-pyran-2-one derivatives with a 96% de. This methodology, which yields the corresponding methyl nor-mevaldates with 99% ee, has been applied to the enantioselective synthesis of the ( )-(R) and (þ)-(S) nor-mevalonic acid lactones.
%K Botrytis cinerea
%K Desymmetrisation
%K meso-Dialdehyde
%K Nor-methyl mevaldate
%~ Universidad de Cádiz