%0 Journal Article 
%A Durán Peña, María Jesús
%A Flores-Giubi, M. E.
%A Botubol Ares, José Manuel
%A M. Harwood, L.
%A González Collado, Isidro
%A Macías Sánchez, Antonio José
%A Hernández Galán, Rosario
%T Chemoselective and stereoselective lithium carbenoid mediated cyclopropanation of acyclic allylic alcohols
%D 2016
%U http://hdl.handle.net/10498/20593
%X The reaction of geraniol with different lithium carbenoids generated from n-BuLi and the corresponding dihaloalkane has been evaluated. The reaction occurs in a chemo and stereoselective manner, which is consistent with a directing effect from the oxygen of the allylic moiety. Furthermore, a set of polyenes containing allylic hydroxyl or ether groups were chemoselectively and stereoselectively converted into the corresponding gem-dimethylcyclopropanes in one single step in moderate to good yields mediated by a lithium carbenoid generated in situ by the reaction of n-BuLi and 2,2-dibromopropane.
%~ Universidad de Cádiz