%0 Journal Article 
%A Pérez-Nadales, Elena
%A Alastruey-Izquierdo, Ana
%A Linares-Sicilia, María José
%A Soto-Debrán, Juan Carlos
%A Abdala, Edson
%A García-Rodríguez, Julio
%A Montejo, Miguel
%A Muñoz, Patricia
%A Salavert Lletí, Miguel
%A Rezusta, Antonio
%A Ruiz Pérez de Pipaón, Maite
%A Yáñez, Lucrecia
%A Merino, Esperanza
%A Campos-Herrero, María Isolina
%A Costa-Mateo, José María
%A Fortún, Jesús
%A García-Lozano, Tomás
%A Garcia-Vidal, Carolina
%A Fernández-Ruiz, Mario
%A Sánchez-Reus, Ferrán
%A Castro-Méndez, Carmen
%A Guerrero Lozano, Inmaculada
%A Soler-Palacín, Pere
%A Aguado, José María
%A Martínez-Martínez, Luis
%A Torre-Cisneros, Julian
%A Nucci, Marcio
%A Spanish Fusariosis Study Group
%T Invasive Fusariosis in Nonneutropenic Patients, Spain, 2000-2015
%D 2021
%@ 1080-6040

%U http://hdl.handle.net/10498/24512
%X Invasive fusariosis (IF) is associated with severe neutropenia in patients with concurrent hematologic conditions. We conducted a retrospective observational study to characterize the epidemiology of IF in 18 Spanish hospitals during 2000-2015. In that time, the frequency of IF in nonneutropenic patients increased from 0.08 cases per 100,000 admissions in 2000-2009 to 0.22 cases per 100,000 admissions in 2010-2015. Nonneutropenic IF patients often had nonhematologic conditions, such as chronic cardiac or lung disease, rheumatoid arthritis, history of solid organ transplantation, or localized fusariosis. The 90-day death rate among nonneutropenic patients (28.6%) and patients with resolved neutropenia (38.1%) was similar. However, the death rate among patients with persistent neutropenia (91.3%) was significantly higher. We used a multivariate Cox regression analysis to characterize risk factors for death: persistent neutropenia was the only risk factor for death, regardless of antifungal therapy.
%~ Universidad de Cádiz