%0 Journal Article 
%A Morales-Ponce, Francisco J.
%A González Pérez, Pablo José
%A Blasco-Turrión, Sara
%A Sánchez-Brotons, Juan Antonio
%A Collado-Moreno, Carmen
%A Martínez-Romero, Pedro
%A Martínez-Morentín, Eduardo
%A Caro-Mateo, Pilar
%T Effects of intracoronary antithrombotics on ventricular function: A comparison of tenecteplase versus abciximab during primary percutaneous intervention in myocardial infarction
%D 2021
%@ 1897-5593

%U http://hdl.handle.net/10498/24794
%X Adjunctive medical therapy during primary
percutaneous coronary intervention (PPCI) is
based on anticoagulation and antiplatelet drugs. Additionally,
the glycoprotein IIb/IIIa inhibitor (GPI)
abciximab has been shown to reduce infarct size in
some clinical trials [1]. However, the role of intracoronary
fibrinolysis has not been well established
during PPCI. We sought to explore the hypothesis
that a locally administered fibrinolytic could be
more effective in dissolving coronary thrombus
at the macro and microvasculature than adding
a third antiplatelet drug in patients already receiving
double antiplatelet therapy, and therefore improve
myocardial perfusion and left ventricular function.
%~ Universidad de Cádiz