%0 Journal Article 
%A Cuevas, Belén
%A Arroba Espinosa, Ana Isabel
%A Reyes Jiménez, Carolina de los
%A Gómez Jaramillo, María Laura
%A González Montelongo, María del Carmen
%A Zubía Mendoza, Eva
%T Diterpenoids from the Brown Alga Rugulopteryx okamurae and Their Anti-Inflammatory Activity
%D 2021
%@ 1660-3397
%U http://hdl.handle.net/10498/26422
%X Brown algae of the Family Dictyotaceae produce an array of structurally diverse terpenoids,
whose biomedical potential in the anti-inflammatory area has been scarcely explored. Herein, the
chemical study of the alga Rugulopteryx okamurae has led to the isolation of ten new diterpenoids:
rugukadiol A (1), rugukamurals A–C (2–4), and ruguloptones A–F (6–10). The structures of the
new compounds were established by spectroscopic means. Compound 1 exhibits an unprecedented
diterpenoid skeleton featuring a bridged tricyclic undecane system. Compounds 2–10 belong to the
secospatane class of diterpenoids and differ by the oxygenated functions that they contain. In antiinflammatory
assays, the new diterpenoid 1 and the secospatanes 5 and 10 significantly inhibited the
production of the inflammatory mediator NO in LPS-stimulated microglial cells Bv.2 and macrophage
cells RAW264.7. Moreover, compounds 1 and 5 were found to strongly inhibit the expression of Nos2
and the pro-inflammatory cytokine Il1b in both immune cell lines.
%K diterpenoids
%K brown algae
%K Rugulopteryx okamurae
%K anti-inflammatory
%K nitric oxide
%K cytokine
%K microglia
%K macrophages
%K invasive algae
%~ Universidad de Cádiz