%0 Journal Article 
%A Montes de Oca García, Adrian
%A Corral Pérez, Juan
%A Velázquez Díaz, Daniel
%A Pérez-Bey, Alejandro
%A Rebollo Ramos, María
%A Marín Galindo, Alberto
%A Gómez-Gallego, Félix
%A Calderón Domínguez, María
%A Casals Vázquez, Cristina
%A Ponce González, Jesús Gustavo
%T Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults
%D 2022
%@ 1664-042X
%U http://hdl.handle.net/10498/27984
%X This study aimed to analyze the influence of the peroxisome proliferator-activated receptor (PPAR)-gamma coactivator (PGC)-1 alpha (PPARGC1A) gene rs8192678 C > T polymorphism on different health-related parameters in male and female young adults. The PPARGC1A gene rs8192678 polymorphism was ascertained by polymerase chain reaction in 74 healthy adults (28 women; 22.72 +/- 4.40 years) from Andalusia (Spain). Health-related variables included cardiometabolic risk, anthropometry and body composition, biochemical parameters, insulin sensitivity (QUICKI and HOMA-IR indexes), blood pressure (BP) at rest and after exercise, diet, basal metabolism, physical activity, maximal fat oxidation, and cardiorespiratory fitness. Our results showed differences by PPARGC1A gene rs8192678 C > T polymorphism in body mass (p = 0.002), body mass index (p = 0.024), lean body mass (p = 0.024), body fat (p = 0.032), waist circumference (p = 0.020), and BP recovery ratio (p < 0.001). The recessive model (CC vs. CT/TT) showed similar results but also with differences in basal metabolism (p = 0.045) and total energy expenditure (p = 0.024). A genotype*sex interaction was found in the QUICKI index (p = 0.016), with differences between CC and CT/TT in men (p = 0.049) and between men and women inside the CT/TT group (p = 0.049). Thus, the PPARGC1A gene rs8192678 C > T polymorphism is associated with body composition, basal metabolism, total energy expenditure, and BP recovery, where the CC genotype confers a protective effect. Moreover, our study highlighted sexual dimorphism in the influence of PPARGC1A gene rs8192678 C > T polymorphism on the QUICKI index.
%K genetic association studies
%K cardiometabolic risk
%K metabolism
%K healthy lifestyle
%K PPARGC1A
%K caucasian, obesity
%K physical exercise
%~ Universidad de Cádiz