%0 Journal Article 
%A Maciel-Silva, Francisco W.
%A Lachos-Perez, Daniel
%A Selene Buller, Luz
%A Sganzerla, William G.
%A Pérez García, Montserrat
%A Rostagno, Mauricio Ariel
%A Forster-Carneiro, Tânia
%T Green Extraction Processes for Complex Samples from Vegetable Matrices Coupled with On-Line Detection System: A Critical Review
%D 2022
%@ 1420-3049
%U http://hdl.handle.net/10498/28691
%X The detection of analytes in complex organic matrices requires a series of analytical steps to obtain a reliable analysis. Sample preparation can be the most time-consuming, prolonged, and error-prone step, reducing the reliability of the investigation. This review aims to discuss the advantages and limitations of extracting bioactive compounds, sample preparation techniques, automation, and coupling with on-line detection. This review also evaluates all publications on this topic through a longitudinal bibliometric analysis, applying statistical and mathematical methods to analyze the trends, perspectives, and hot topics of this research area. Furthermore, state-of-the-art green extraction techniques for complex samples from vegetable matrices coupled with analysis systems are presented. Among the extraction techniques for liquid samples, solid-phase extraction was the most common for combined systems in the scientific literature. In contrast, for on-line extraction systems applied for solid samples, supercritical fluid extraction, ultrasound-assisted extraction, microwave-assisted extraction, and pressurized liquid extraction were the most frequent green extraction techniques.
%K sample preparation
%K green extraction techniques
%K on-line coupling
%K fully automated analysis
%K bibliometric analysis
%~ Universidad de Cádiz