%0 Journal Article 
%A Montes Herrera, Antonio
%A Wehner, Lukas
%A Pereyra López, Clara María
%A Martínez de la Ossa Fernández, Enrique José
%T Mangiferin nanoparticles precipitation by supercritical antisolvent process
%D 2016
%@ 0896-8446
%U http://hdl.handle.net/10498/29987
%X Nano and microparticle of mangiferin were precipitated by supercritical antisolvent (SAS) process. A preliminary study of typical solvent used in SAS process was carried out in order to select a solvent or mixtures of them with a good miscibility with supercritical CO2. Mixtures of acetone with dimethyl sulphoxide and 1-methyl-2-pyrrolidone led to submicron particles with spherical morphology. The study of the main parameter, that could affect the nano or micro precipitation, was carried out using acetone with dimethyl sulphoxide instead of 1-methyl-2-pyrrolidone because the low toxicity. Higher CO2 and liquid solution flow rates, higher pressures, lower temperatures and lower nozzle diameter are recommended to the nanoparticle production. Morphologies of the precipitates were analyzed by scanning electron microscopy (SEM). X-ray Diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR) were carried out to find out the possible loss of crystallinity and activity of the precipitates. Dissolution profiles of mangiferin were carried out in simulated fluids and processed mangiferin was dissolved faster and with higher solubility than raw material. This fact would permit its use in pharmaceutical, cosmetic or nutraceutical applications.

%~ Universidad de Cádiz