%0 Journal Article 
%A Simonet Morales, Ana María
%A Silva, Naiara C.
%A Dias, Amanda L.T.
%A Vilegas, Wagner
%A Macías Domínguez, Francisco Antonio
%A Dias Silva, Marcelo J.
%T Bioassay-Guided Isolation of Fungistatic Compounds from Mimosa caesalpiniifolia Leaves
%D 2019
%@ 1520-6025

%U http://hdl.handle.net/10498/30395
%X A bioassay-guided phytochemical study of a Mimosa caesalpiniifolia leaf extract with antifungal activity
permitted the identification of 28 compounds, including the new 6-(β-boivinopyranosyl)apigenin (1), 8-(β-oliopyranosyl)-apigenin (2), (E)-6-(2-carboxyethenyl)apigenin (3), (E)-8-(2-carboxyethenyl)apigenin (4), and 7,5″-anhydro-6-(α-2,6-dideoxy-5-hydroxyarabinohexopyranosyl)apigenin (5). The structures of the new compounds were determined by comprehensive spectroscopic analysis, including 1D and 2D
NMR techniques, and by mass spectrometry. Compound 3 showed promising activity and selectivity against Candida krusei (IC50 44 nM), which exhibits resistance to azoles. The association of the major components 3-β-D-glucopyranosyloxysitosterol (8) and ethyl gallate (10) was synergistic against C.
krusei, especially the IC values of compound 10, which were reduced by more than 100-fold.
%K Mimosa caesalpiniifolia
%K fungistatic
%K flavonoids
%K synergistic interaction
%~ Universidad de Cádiz