%0 Journal Article 
%A Oliviero, A
%A Carrasco-López, MC
%A Campolo, M
%A Perez-Borrego, Y
%A Soto Leon, Vanesa
%A González Rosa, Javier Jesús
%A Higuero, AM
%A Strange, BA
%A Abad-Rodriguez, J
%A Foffani, G
%T Safety Study of Transcranial Static Magnetic Field Stimulation (tSMS) of the Human Cortex
%D 2015
%@ 1935-861X
%U http://hdl.handle.net/10498/30688
%X Background: Transcranial static magnetic field stimulation (tSMS) in humans reduces cortical excitability.

Objective: The objective of this study was to determine if prolonged tSMS (2 h) could be delivered safely in humans. Safety limits for this technique have not been described.

Methods: tSMS was applied for 2 h with a cylindric magnet on the occiput of 17 healthy subjects. We assessed tSMS-related safety aspects at tissue level by measuring levels of neuron-specific enolase (NSE, a marker of neuronal damage) and S100 (a marker of glial reactivity and damage). We also included an evaluation of cognitive side effects by using a battery of visuomotor and cognitive tests.

Results: tSMS did not induce any significant increase in NSE or S100. No cognitive alteration was detected.

Conclusions: Our data indicate that the application of tSMS is safe in healthy human subjects, at least within these parameters.
%K NIBS
%K Neuron-specific enolase
%K Repetitive transcranial magnetic stimulation (rTMS)
%K S100
%K Safety
%K Transcranial static magnetic field stimulation (tSMS)
%~ Universidad de Cádiz