%0 Journal Article 
%A Chahboun, Rachid
%A Botubol Ares, José Manuel
%A Durán Peña, María Jesús
%A Jiménez, Fermín
%A Álvarez Manzaneda, Ramón
%A Álvarez Manzaneda, Enrique
%T Deconjugative α-alkylation of cyclohexenecarboxaldehydes: An access to diverse terpenoids
%D 2021
%@ 1520-6904

%U http://hdl.handle.net/10498/30957
%X A general and efficient method for the deconjugative
α-alkylation of α,β-unsaturated aldehydes promoted by a
synergistic effect between tBuOK and NaH, which considerably
increases the reaction rate under mild conditions, is reported. The
β,γ-unsaturated aldehyde, resulting from the α-alkylation, is
transformed in high yield into the corresponding allyl acetate via
a lead(IV) acetate-mediated oxidative fragmentation. This strategy
could be used for the construction of the carbon skeleton of a wide
variety of alkyl or arylterpenoids.
%~ Universidad de Cádiz