%0 Journal Article 
%A Aguado Vidal, Enrique
%A Call, M.E.
%T Editorial: Methods in T cell biology: 2022
%D 2023
%@ 1664-3224
%U http://hdl.handle.net/10498/31473
%X T cells are crucial players of immune responses by their ability to specifically recognize
foreign, potentially harmful, antigens. To perform such specific recognition, T cells express
at their plasma membrane an antigen receptor called the T cell receptor (TCR) (1–3). The
TCR expressed at the plasma membrane in the majority of T cells is composed by a TCR-a
and TCR-b heterodimer, which is able to recognize a complex formed by an antigenic
peptide coupled to an MHC molecule (pMHC complex). After specific recognition by a
pMHC complex the TCR triggers multiple intracellular signals leading to proliferation,
target cell killing, cytokine secretion, and differentiation into effector T cells. Although our
understanding of the molecular mechanisms governing activation of T cells has
dramatically grown in recent years, there is still much to learn
%K binding prediction
%K machine learning
%K method
%K T cell
%K T cell epitope
%K TCR (T cell receptor)
%~ Universidad de Cádiz