%0 Journal Article 
%A Pérez Arana, Gonzalo Martín
%A Díaz Gómez, Alfredo Luis
%A Bancalero-de los Reyes, José
%A Gracia Romero, Manuel Ángel
%A Ribelles García, Antonio
%A Visiedo García, Francisco Manuel
%A González Domínguez, Álvaro
%A Almorza Gomar, David
%A Prada Oliveira, José Arturo
%T The role of glucagon after bariatric/metabolic surgery: much more than an “anti-insulin” hormone
%D 2023
%@ 1664-2392
%U http://hdl.handle.net/10498/31488
%X The biological activity of glucagon has recently been proposed to both stimulate hepatic glucose production and also include a paradoxical insulinotropic effect, which could suggest a new role of glucagon in the pathophysiology type 2 diabetes mellitus (T2DM). An insulinotropic role of glucagon has been observed after bariatric/metabolic surgery that is mediated through the GLP-1 receptor on pancreatic beta cells. This effect appears to be modulated by other members of the proglucagon family, playing a key role in the beneficial effects and complications of bariatric/metabolic surgery. Glucagon serves a dual role after sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB). In addition to maintaining blood glucose levels, glucagon exhibits an insulinotropic effect, suggesting that glucagon has a more complex function than simply an “anti-insulin hormone”.
%K alpha cell
%K diabetes
%K glucagon
%K glucose
%K incretin
%K Roux-en-Y gastric bypass
%K sleeve gastrectomy
%~ Universidad de Cádiz