%0 Journal Article 
%A González, Jessica
%A Batlle, Jordi
%A Benítez, Iván D.
%A Torres, Gerard
%A Santisteve, Sally
%A Targa, Adriano D.S.
%A Gort Paniello, Clara
%A Moncusí Moix, Anna
%A Aguilà, Maria
%A Seck, Fatty
%A Ceccato, Adrián
%A Ferrer, Ricard
%A Motos, Anna
%A Riera, Jordi
%A Fernández, Laia
%A Menéndez, Rosario
%A Lorente, José A.
%A Peñuelas, Oscar
%A García Gasulla, Dario
%A Peñasco, Yhivian
%A Ricart, Pilar
%A Abril Palomares, Elena
%A Aguilera, Luciano
%A Rodríguez, Alejandro
%A Boado Varela, Maria Victoria
%A Beteré, Belén
%A Pozo-Laderas, Juan Carlos
%A Solé Violán, Jordi
%A Salvador-Adell, Inmaculada
%A Andrea Novo, Mariana
%A Barberán, José
%A Amaya Villar, Rosario
%A Garnacho-Montero, José
%A Gómez, José M.
%A Blandino Ortiz, Aaron
%A Tamayo Lomas, Luis
%A Úbeda, Alejandro
%A Catalán‑González, Mercedes
%A Sánchez Miralles, Ángel
%A Gumucio-Sanguino, Víctor D.
%A Bustamante Munguira, Elena
%A Valdivia, Luis Jorge
%A Caballero, Jesús
%A Gallego, Elena
%A Rodríguez, Covadonga
%A Castellanos Ortega, Álvaro
%A Trenado, Josep
%A Marin Corral, Judith
%A Albaiceta, Guillermo M.
%A de la Torre, María del Carmen
%A Loza Vázquez, Ana
%A Vidal, Pablo
%A Añón, José Manuel
%A Carbajales Pérez, Cristina
%A Sagredo, Víctor
%A Carbonell, Nieves
%A Socias, Lorenzo
%A Barberà, Carme
%A Estella García, Ángel
%A Díaz, Emili
%A de Gonzalo Calvo, David
%A Torres, Antoni
%A Barbé, Ferrán
%A Cabello, M. A.
%A Alcaraz-Serrano, V.
%A Aldecoa, C.
%A Alegre, C.
%A Calderón, Á. A.
%A Álvarez, S.
%A Bardi, T.
%A Segade, P. B.
%A Barroso, M.
%A García, J.Á.B
%A Bermejo, J.
%A Bigas, J.
%A Blancas, R.
%A Cortés, M. L. B.
%A Saera, M.B.
%A Bofill, N.
%A Vieiro, M.T.B.
%A Bueno, L.
%A Bustamante Munguira, Juan
%A Martínez, C. B. D.
%A Hermoso, D. C.
%A Fernández, S.C.
%A Cano, I.
%A Canseco, J.
%A Fernández, P. C.
%A García, L. C.
%A Carvalho, S.
%A Castellà, M.
%A Castellví, A.
%A Castro, P.
%A Centelles-Serrano, M.J.
%A Ávila, R.C.
%A Cillóniz, C.
%A Clar, L.
%A Climent, C.
%A Codina, J.
%A Conde, P.
%A Contreras, S.
%A Parra, R.D.F.
%A Sánchez, R.D.P.
%A Mendoza, D.D.
%A Díaz, Y.
%A Vilas, M.D.R.
%A Moreno, C.D.
%A Dot, I.
%A Giraudo, P.E.
%A Arijón, I.E.
%A Monjo, T.F.
%A Fernández, J.
%A Ferrando, C.
%A Figueras, A.
%A Gomà, G.
%A Casal, V.G.
%A Gómez, S.
%A Gonzalez, C.G.
%A Gordo, F.
%A Gracia, M.P.
%A Fernández, M.J.G.
%A Herraiz, A.
%A Herrán-Monge, R.
%A Ibarz, M.
%A Iglesias, S.
%A Mantellini, C. L.
%A Naya, G. M.
%A Barcos, I. M.
%A Marcos, P.
%A Peis, E. M.
%A Cuadrado, M. M.
%A Delgado, M. C. M.
%A Vicente, P. M.
%A Martínez, P. M.
%A Fernández, C.E.M.
%A Juan, M. D. M.
%A Palacios, B.M.
%A Jiménez, J. F. M.
%A Masclans, J. R.
%A Maseda, E.
%A Fernández, E. M. M.
%A Banderas, P. M.
%A Mínguez, O.
%A Miralbés, M.
%A Monclou, J.
%A Montejo-González, J. C.
%A Montserrat, N.
%A Aznar, M. M.
%A Morales, D.
%A Cano, S.G.M.
%A Rodríguez, D. M.
%A Muñoz-Bermúdez, R.
%A Nicolás, J.M.
%A Bou, R.N.
%A Salinas, R.N.
%A Ocón, M.
%A Ortega, A.
%A Ossa, S.
%A Pagliarani, P.
%A Parrilla, F.
%A Pedregosa-Díaz, J.
%A Bastida, L. P.
%A Pérez, P.
%A Pérez-García, F.
%A Planelles, G. P.
%A Rubio, E. P.
%A Laguna, D.P.
%A Prados, J.
%A Pujol, A.
%A Coll, N. R.
%A Sánchez-Girón, G.R.
%A Roche-Campo, F.
%A Rodríguez, L.
%A Castro, F. R. D.
%A Rodríguez, S.
%A Ruiz, C. R.
%A Rubio, J.
%A Pensado, M. S.
%A Serra, L.
%A Serra-Fortuny, M.
%A Lázaro, A. S.
%A Servià, L.
%A Soliva, L.
%A Speziale, C.
%A Tormos, A.
%A Torres, M.
%A Tranque-Liberal, C.
%A Trefler, S.
%A Trujillano, J.
%A Vaca, R.
%A Val, E.
%A Ruiz, L. V.
%A Vallverdú, M.
%A Martín-Montalvo, M. V. D. H.
%A Adrio, S.V.
%A Vázquez, N.
%A Vengoechea, J.
%A Vilà-Vilardel, C.
%A Vilanova, J.
%A Warrington, T.V.
%A Yang, H.
%A Yang, M.
%A Zapatero, A.
%T Key Factors Associated With Pulmonary Sequelae in the Follow-Up of Critically Ill COVID-19 Patients
%D 2023
%@ 1579-2129

%U http://hdl.handle.net/10498/31730
%X Introduction: Critical COVID-19 survivors have a high risk of respiratory sequelae. Therefore, we aimed to identify key factors associated with altered lung function and CT scan abnormalities at a follow-up visit in a cohort of critical COVID-19 survivors. Methods: Multicenter ambispective observational study in 52 Spanish intensive care units. Up to 1327 PCR-confirmed critical COVID-19 patients had sociodemographic, anthropometric, comorbidity and lifestyle characteristics collected at hospital admission; clinical and biological parameters throughout hospital stay; and, lung function and CT scan at a follow-up visit. Results: The median [p25–p75] time from discharge to follow-up was 3.57 [2.77–4.92] months. Median age was 60 [53–67] years, 27.8% women. The mean (SD) percentage of predicted diffusing lung capacity for carbon monoxide (DLCO) at follow-up was 72.02 (18.33)% predicted, with 66% of patients having DLCO < 80% and 24% having DLCO < 60%. CT scan showed persistent pulmonary infiltrates, fibrotic lesions, and emphysema in 33%, 25% and 6% of patients, respectively. Key variables associated with DLCO < 60% were chronic lung disease (CLD) (OR: 1.86 (1.18–2.92)), duration of invasive mechanical ventilation (IMV) (OR: 1.56 (1.37–1.77)), age (OR [per-1-SD] (95%CI): 1.39 (1.18–1.63)), urea (OR: 1.16 (0.97–1.39)) and estimated glomerular filtration rate at ICU admission (OR: 0.88 (0.73–1.06)). Bacterial pneumonia (1.62 (1.11–2.35)) and duration of ventilation (NIMV (1.23 (1.06–1.42), IMV (1.21 (1.01–1.45)) and prone positioning (1.17 (0.98–1.39)) were associated with fibrotic lesions. Conclusion: Age and CLD, reflecting patients’ baseline vulnerability, and markers of COVID-19 severity, such as duration of IMV and renal failure, were key factors associated with impaired DLCO and CT abnormalities.
%K COVID-19
%K CT abnormalities
%K ICU
%K Lung function
%K Sequelae
%~ Universidad de Cádiz