%0 Journal Article 
%A Lubián Gutiérrez, Manuel
%A Benavente Fernández, Isabel
%A Marín-Almagro, Y.
%A Jiménez Luque, Natalia
%A Zuazo Ojeda, Mirem Amaya
%A Sánchez Sandoval, Yolanda
%A Lubián López, Simón Pedro
%T Corpus callosum long-term biometry in very preterm children related to cognitive and motor outcomes
%D 2024
%@ 1530-0447

%U http://hdl.handle.net/10498/32760
%X BACKGROUND: The corpus callosum (CC) is suggested as an indirect biomarker of white matter volume, which is often affected in
preterm birth. However, diagnosing mild white matter injury is challenging.
METHODS: We studied 124 children born preterm (mean age: 8.4 ± 1.1 years), using MRI to assess CC measurements and cognitive/
motor outcomes based on the Wechsler Intelligence Scale for Children-V (WPPSI-V) and Movement Assessment Battery for
Children-2 (MABC-2).
RESULTS: Children with normal outcomes exhibited greater height (10.2 ± 2.1 mm vs. 9.4 ± 2.3 mm; p = 0.01) and fractional
anisotropy at splenium (895[680–1000] vs 860.5[342–1000]) and total CC length (69.1 ± 4.8 mm vs. 67.3 ± 5.1 mm; p = 0.02)
compared to those with adverse outcomes. All measured CC areas were smaller in the adverse outcome group. Models
incorporating posterior CC measurements demonstrated the highest specificity (83.3% Sp, AUC: 0.65) for predicting neurological
outcomes. CC length and splenium height were the only linear measurements associated with manual dexterity and total MABC-2
score while both the latter and genu were related with Full-Scale Intelligence Quotient.
CONCLUSIONS: CC biometry in children born very preterm at school-age is associated with outcomes and exhibits a specific
subregion alteration pattern. The posterior CC may serve as an important neurodevelopmental biomarker in very preterm infants.
%~ Universidad de Cádiz