%0 Journal Article 
%A Alías-Ferri, María
%A García-Marchena, Nuria
%A Mestre-Pintó, Joan
%A Araos, Pedro
%A Vergara Moragues, Esperanza
%A Fonseca, Francina
%A González Saiz, Francisco Manuel
%A Rodríguez de Fonseca, Fernando
%A Torrens, Marta
%A NEURODEP, Group
%T Cocaine and depressive disorders: When standard clinical diagnosis is insufficient
%D 2021
%@ 0214-4840
%U http://hdl.handle.net/10498/33106
%X Background: Cocaine use is a growing global health problem and patients with cocaine use disorders (CUD) present several complications, including high rates of major depression. These subjects present two types of major depressive disorder (MDD): primary major depressive disorder (P-MDD) and cocaine-induced major depressive disorder (CI-MDD). To improve treatment, it is necessary to distinguish between both types. The aim of this study was to assess the differences in depressive symptomatology criteria (P-MDD vs CI-MDD) in CUD patients.

Methods: Secondary data analysis was carried out with a cross-sectional sample of 160 patients presenting CUD and MDD. Clinical assessment was performed using the Psychiatric Research Interview for Substance and Mental Disorders (PRISM). A differential diagnosis was obtained between P-MDD and CI-MDD.

Results: Men represented 80% of the sample, the mean age was 38.61 years, and 64.5% had elementary studies. CI-MDD diagnosis (61.3%) was more frequent than P-MDD (38.7%). There was a younger age of CUD onset in CI-MDD patients. In addition, 79.4% of the patients had another substance use disorder diagnosis. The criterion "Changes in weight or appetite" was more prevalent (57.1%) in P-MDD group.

Conclusions: We found differences in the criterion "Changes in weight or appetite". Further research is needed in this field to establish a differential diagnosis and thus provide better treatment for CUD patients.
%K Dual diagnosis
%K cocaine use disorder
%K cocaine-related disorders
%K depressive disorder
%K induced depression
%~ Universidad de Cádiz