%0 Journal Article 
%A Iglesia, I.
%A Huybrechts, I.
%A González Gross, M.
%A Mouratidou, T.
%A Santabárbara, J.
%A Chajès, V.
%A González Gil, E. M.
%A Park, J. Y.
%A Bel Serrat, S.
%A Cuenca García, María Magdalena
%A Castillo, M.
%A Kersting, M.
%A Widhalm, K.
%A De Henauw, S.
%A Sjöström, M.
%A Gottrand, F.
%A Molnár, D.
%A Manios, Y.
%A Kafatos, A.
%A Ferrari, M.
%A Stehle, P.
%A Marcos, A.
%A Sánchez Muniz, F. J.
%A Moreno, L. A.
%T Folate and Vitamin B12 concentrations are associated with plasma DHA and EPA fatty acids in European adolescents: The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study
%D 2017
%@ 1475-2662

%U http://hdl.handle.net/10498/34163
%X This study aimed to examine the association between vitamin B6, folate and vitamin B12 biomarkers and plasma fatty acids in European
adolescents. A subsample from the Healthy Lifestyle in Europe by Nutrition in Adolescence study with valid data on B-vitamins and fatty acid
blood parameters, and all the other covariates used in the analyses such as BMI, Diet Quality Index, education of the mother and physical
activity assessed by a questionnaire, was selected resulting in 674 cases (43 % males). B-vitamin biomarkers were measured by
chromatography and immunoassay and fatty acids by enzymatic analyses. Linear mixed models elucidated the association between B-vitamins
and fatty acid blood parameters (changes in fatty acid profiles according to change in 10 units of vitamin B biomarkers). DHA, EPA) and n-3
fatty acids showed positive associations with B-vitamin biomarkers, mainly with those corresponding to folate and vitamin B12. Contrarily,
negative associations were found with n-6:n-3 ratio, trans-fatty acids and oleic:stearic ratio. With total homocysteine (tHcy), all the
associations found with these parameters were opposite (for instance, an increase of 10 nmol/l in red blood cell folate or holotranscobalamin
in females produces an increase of 15·85 µmol/l of EPA (P value <0·01), whereas an increase of 10 nmol/l of tHcy in males produces a
decrease of 2·06 µmol/l of DHA (P value <0·05). Positive associations between B-vitamins and specific fatty acids might suggest underlying
mechanisms between B-vitamins and CVD and it is worth the attention of public health policies
%K Fatty acids
%K B-vitamins
%K Adolescents
%K Europe
%~ Universidad de Cádiz