%0 Journal Article 
%A Santotoribio, Jose D.
%A Corral Pérez, Juan
%A Nuñez Jurado, David
%A Fatela Cantillo, Daniel
%A García de la Torre, Ángela
%A Orantes Maroto, Gabirel
%A Del Valle Vázquez, Luis
%A Del Castillo Otero, Daniel
%A Maira González, María Nieves
%A Cobos Diaz, Andrés
%A Juan M, Guerrero
%A López Sáez, José Juan Bosco
%T Malignant Pleural Effusion Risk Based On A Novel Tool Using Homocysteine And Carcinoembryonic Antigen In Pleural Fluid: A Multicenter Study
%D 2024
%@ 1873-2933

%U http://hdl.handle.net/10498/34336
%X Introduction
This multicenter study aimed to evaluate the Malignant Pleural Effusion Risk (MPER) diagnostic accuracy in distinguishing between benign and malign pleural effusion. Methods: MPER is based on pleural fluid Homocysteine (HCY) and carcinoembryonic antigen (CEA) that were measured using three different methods. MPER was calculated by assessing a previously published probabilistic model: Probability (%) = 100× (1 + e-z)-1, where Z = 0.5471 × [HCY] + 0.3846 × [CEA]–8.2671.
Results
A total of 301 patients were included (140 MPE). MPER demonstrated a high AUC (0.891), sensitivity (84.3 %), and specificity (80.7 %) with a cut-off > 35.3 %.
Conclusions
The MPER model demonstrated a high diagnostic accuracy supporting its use as a novel and powerful tool.Introduction
This multicenter study aimed to evaluate the Malignant Pleural Effusion Risk (MPER) diagnostic accuracy in distinguishing between benign and malign pleural effusion. Methods: MPER is based on pleural fluid Homocysteine (HCY) and carcinoembryonic antigen (CEA) that were measured using three different methods. MPER was calculated by assessing a previously published probabilistic model: Probability (%) = 100× (1 + e-z)-1, where Z = 0.5471 × [HCY] + 0.3846 × [CEA]–8.2671.
Results
A total of 301 patients were included (140 MPE). MPER demonstrated a high AUC (0.891), sensitivity (84.3 %), and specificity (80.7 %) with a cut-off > 35.3 %.
Conclusions
The MPER model demonstrated a high diagnostic accuracy supporting its use as a novel and powerful tool.
%~ Universidad de Cádiz