%0 Journal Article 
%A Reyes Jiménez, Carolina de los
%A Zbakh, Hanna
%A Motilva, Virginia
%A Zubía Mendoza, Eva
%T Antioxidant and Anti-inflammatory Meroterpenoids from the Brown Alga Cystoseira usneoides
%D 2013
%@ 0163-3864

%U http://hdl.handle.net/10498/34727
%X A chemical study of the alga Cystoseira usneoides has led to the isolation of six new meroterpenoids, cystodiones A−F (1−6), together with six known related compounds (7−12). The structures of the new metabolites have been established by spectroscopic techniques. In antioxidant assays all of the tested meroterpenes, and in particular cystodiones A (1) and B (2), 6-cis-amentadione-1′-methyl ether (7), and amentadione-1′ methyl ether (8), exhibited strong radical-scavenging activity. In antiinflammatory assays, usneoidone Z (11) and its corresponding 6E isomer (12) showed significant activity as inhibitors of the production of the proinflammatory cytokine TNF-α in LPS-stimulated THP-1 human macrophages.
%~ Universidad de Cádiz