%0 Journal Article 
%A Girón González, José Antonio
%A Baturone, Rocio
%A Soto, Maria José
%A Márquez Coello, María de las Mercedes
%A Macias, Inmaculada
%A Montes de Oca, Montserrat
%A Medina, Fermín
%A Chozas Candanedo, Nicolás
%A García-Perez, S
%T Implications of immunomodulatory interleukins for the hyperimmunoglobulinemia of Sjögren's syndrome
%D 2009
%@ 0008-8749
%U http://hdl.handle.net/10498/34948
%X A prospective study of 37 patients with pSS and 20 healthy controls was performed to analyze the differences in circulating levels of macrophage-derived and Th1/Th2 cytokines which could explain the hyperimmunoglobulinemia, characteristic of primary Sjögren’s syndrome (pSS). Serum levels of interleukin (IL)-6, IL-10, IL-12, gamma-interferon (γ-INF) and IL-4 were analyzed by a sandwich immunoassay-based protein array system. When compared with the control group, higher levels of IL-6, IL-12 and IL-10 and a lower Th1/Th2 ratio, as demonstrated by the γ-INF/IL-4 ratio, were detected in patients. The levels of IL-4 were notably higher in pSS patients with monoclonal gammopathy. Serum IL-4 and IL-10 levels and immunoglobulin G concentrations were significantly correlated. In conclusion, patients with pSS show a state of macrophage and T-lymphocyte activation with increased concentrations of cytokines implicated in the differentiation of B cells and secretion of immunoglobulins.
%~ Universidad de Cádiz