%0 Journal Article 
%A Ortega-Vidal, J.
%A Reddy, M. M.
%A Pérez-Fuentes, N.
%A Alvariño, R.
%A Burth, S.
%A Alfonso, A.
%A Vale, C.
%A Roca Virués de Segovia, Jorge
%A Mungkaje, A.
%A Botana, L. M.
%A Thomas, O. P.
%T Contignasterines, Anti-Inflammatory 2-Aminoimidazole Steroids from the Sponge Neopetrosia cf. rava Collected in the Bismarck Sea
%D 2025
%@ 1520-6025

%U http://hdl.handle.net/10498/36918
%X Sponges of the genus Neopetrosia are known for the
production of a large diversity of bioactive metabolites.
Contignasterines A (1) and B (2) were isolated as major
metabolites of the sponge Neopetrosia cf. rava collected in the
Bismarck Sea along with the known and highly bioactive steroid
contignasterol (3) possessing a similar oxidized aglycone.
Contignasterines are characterized by the presence of a 2-
aminoimidazole branched on the side-chains of the oxidized
steroid, and 1 also contains an unusual phosphate group at C-7.
The anti-inflammatory activities of these compounds were
investigated and revealed that all three compounds inhibited the
production of pro-inflammatory mediators
%~ Universidad de Cádiz