%0 Journal Article 
%A Barbeta, Enric
%A Barreiros, Cláudia
%A Forin, Edoardo
%A Guzzardella, Amedeo
%A Motos, Anna
%A Fernández Barat, Laia
%A Gabarrús, Albert
%A Ceccato, Adrián
%A Ferrer, Ricard
%A Riera, Jordi
%A Peñuelas, Oscar
%A Lorente, José A.
%A de Gonzalo Calvo, David
%A González, Jessica
%A Amaya Villar, Rosario
%A Añón, José Manuel
%A Balan, Ana
%A Barberà, Carme
%A Barberán, José
%A Blandino, Aaron
%A Boado, María Victoria
%A Bustamante Munguira, Elena
%A Caballero, Jesús
%A Cantón-Bulnes, Luisa
%A Carbajales, Cristina
%A Carbonell, Nieves
%A Catalán‑González, Mercedes
%A Franco, Nieves
%A Galban, Cristóbal
%A Gumucio-Sanguino, Víctor D.
%A de la Torre, María del Carmen
%A Díaz, Emilio
%A Estella García, Ángel
%A Gallego, Elena
%A Gómez, José Manuel
%A Huerta, Arturo
%A Jorge García, Ruth Noemí
%A Loza Vázquez, Ana
%A Marin Corral, Judith
%A Martín Delgado, María Cruz
%A Martínez, Amalia
%A Martínez, Ignacio
%A López, Juan
%A Albaiceta, Guillermo M.
%A Nieto, María Teresa
%A Andrea Novo, Mariana
%A Peñasco, Yhivian
%A Pérez García, Felipe
%A Ricart, Pilar
%A Rodríguez, Alejandro
%A Sagredo, Víctor
%A Sánchez Miralles, Ángel
%A Sancho, Susana
%A Roche-Campo, Ferran
%A Socias, Lorenzo
%A Solé Violán, Jordi
%A Tamayo, Luis
%A Trenado, José
%A Úbeda, Alejandro
%A Valdivia, Luis Jorge
%A Vidal, Pablo
%A Barbé, Ferrán
%A Vallverdú, Jordi
%A Torres, Antoni
%A CIBERESUCICOVID Project investigators (COV20/00110, ISCIII)
%T Mechanical power is not associated with mortality in COVID-19 mechanically ventilated patients
%D 2025
%@ 2110-5820
%U http://hdl.handle.net/10498/36978
%X Background The relative contribution of the diferent components of mechanical power to mortality is a subject
of debate and has not been studied in COVID-19. The aim of this study is to evaluate both the total and the rela‑
tive impact of each of the components of mechanical power on mortality in a well-characterized cohort of patients
with COVID-19-induced acute respiratory failure undergoing invasive mechanical ventilation. This is a secondary
analysis of the CIBERESUCICOVID project, a multicenter observational cohort study including ffty Spanish intensive
care units that included COVID-19 mechanically ventilated patients between February 2020 and December 2021. We
examined the association between mechanical power and its components (elastic static, elastic dynamic, total elastic
and resistive power) with 90-day mortality after adjusting for confounders in seven hundred ninety-nine patients
with COVID-19-induced respiratory failure undergoing invasive mechanical ventilation.
Results At the initiation of mechanical ventilation, the PaO2/FiO2 ratio was 106 (78; 150), ventilatory ratio was 1.69
(1.40; 2.05), and respiratory system compliance was 35.7 (29.2; 44.5) ml/cmH2O. Mechanical power at the initiation
of mechanical ventilation was 24.3 (18.9; 29.6) J/min, showing no signifcant changes after three days. In multivariable
regression analyses, mechanical power and its components were not associated with 90-day mortality at the start
of mechanical ventilation. After three days, total elastic and elastic static power were associated with higher 90-day
mortality, but this relationship was also found for positive end-expiratory pressure Conclusions Neither mechanical power nor its components were independently associated with mortality in COVID19-induced acute respiratory failure at the start of MV. Nevertheless, after three days, static elastic power and total
elastic power were associated with lower odds of survival. Positive end-expiratory pressure and plateau pressure,
however, captured this risk in a similar manner.
%K Mechanical power
%K COVID-19
%K Mechanical ventilation
%K Respiratory failure
%~ Universidad de Cádiz