%0 Journal Article 
%A Roodveldt, Cintia
%A Labrador, Adahir
%A Gonzalez-Rey, Elena
%A Fernández Montesinos, Rafael
%A Caro, Marta
%A Lachaud, Christian
%A Waudby, Christopher
%A Delgado, Mario
%A Dobson, Christopher
%A Pozo, David
%T Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants.
%D 2010
%@ 1932-6203
%U http://hdl.handle.net/10498/38862
%X Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized pathologically by the presence in the brain of intracellular protein inclusions highly enriched in aggregated alpha-synuclein (α-Syn). Although it has been established that progression of the disease is accompanied by sustained activation of microglia, the underlying molecules and factors involved in these immune-triggered mechanisms remain largely unexplored. Lately, accumulating evidence has shown the presence of extracellular α-Syn both in its aggregated and monomeric forms in cerebrospinal fluid and blood plasma. However, the effect of extracellular α-Syn on cellular activation and immune mediators, as well as the impact of familial PD-linked α-Syn mutants on this stimulation, are still largely unknown

%~ Universidad de Cádiz