%0 Journal Article 
%A Biel-Maeso, Miriam
%A Baena Nogueras, Rosa María
%A Corada Fernández, Carmen
%A Lara Martín, Pablo Antonio
%T Occurrence, distribution and environmental risk of pharmaceutically active compounds (PhACs) in coastal and ocean waters from the Gulf of Cadiz (SW Spain)
%D 2018
%@ 0048-9697
%U http://hdl.handle.net/10498/39036
%X In this study, we have evaluated the occurrence and distribution of 78 pharmaceuticals in different aquatic marine environments from the Gulf of Cadiz (SWSpain) for the first time. The obtained results  revealed that pharmaceuticalswere present in seawater at total concentrations ranging 61–2133 and 16–189 ng L−1 in coastal and oceanic transects, respectively. Potential marine pollution hotspots were observed in enclosed or semi-enclosed water bodies (Cadiz Bay), showing concentrations that were one or two orders of magnitude higher than in the open ocean. The presence of these chemicals in local sewage treatment plants (STPs), one of the main contamination sources, was also assessed, revealing total concentrations of up to 23 μg L−1 in effluents. PhACs with the highest detection frequencies and concentrations in the sampling region were analgesics and antiinflammatories followed by antibiotics in the case of samples fromCadiz Bay or caffeine in oceanic seawater samples. Risk quotients, expressed as ratios between the measured environmental concentration (MEC) and the predicted no-effect concentrations (PNEC) were higher than 1 for two compounds (gemfibrozil and ofloxacin) in effluent of Jerez de la Frontera sewage treatment plant (STP). No high environmental risk was detected in both
coastal and oceanic sampling areas, although the information available about the effects of these chemicals on marine biota is still very limited and negative effects on non-target species cannot be discarded.
%K Pharmaceuticals
%K Antibiotics
%K Seawater
%K Wastewater
%K Environmental risk assessment
%~ Universidad de Cádiz