%0 Journal Article 
%A Ruano González, Antonio
%A Pinto, Ana Andreina
%A Mancilla, Gabriela
%A Sánchez Maestre, Rosario
%A Aleu, Josefina
%A Hernández Galán, Rosario
%A Macías Sánchez, Antonio José
%A González Collado, Isidro
%T Synthesis of Farnesyloxy- and Drimanyloxy-Arene Scaffold-Based Hybrid Molecules as Antifungals against Botrytis cinerea
%D 2025
%@ 1520-5118

%U http://hdl.handle.net/10498/39311
%X There is an increasing interest in the use of biopesticides, which implies the use of living microorganisms, plant and
microbial extracts, and natural products isolated from the above-mentioned sources or closely related derivatives. In this regard, 10
farnesyloxy-arenes derivatives (21−25, (±)-26−(±)-30) and 12 drimanyloxyarenes derivatives ((±)-12−(±)-14, (±)-31−(±)-40)
were synthesized and tested against the phytopathogenic fungus Botrytis cinerea. In general, the drimanyloxyarenes derivatives were
more fungitoxic than their farnesyloxyarene precursors. The most active compounds were (±)-12, (±)-31, and (±)-35, which at a
391 × 10−5 mg/mL dose, were more active than azoxystrobin, while (±)-12 presented an inhibition comparable to that of triclosan.
Structure−activity relationships are discussed, as well as the correlation with calculated physicochemical properties such as logP and
total polar surface area.
%K Botrytis cinerea
%K phytopathogenic fung
%K antifungal
%K hybrid molecules
%K farnesyloxyarenes
%K drimanyloxyarenes
%~ Universidad de Cádiz