%0 Journal Article 
%A Abalos Martínez, Jessica
%A Visiedo García, Francisco Manuel
%A Cascajo Almenara, María Victoria
%A Santos Rosendo, Celeste
%A Melero Jiménez, Victoria
%A Santos Ocaña, Carlos
%A Vázquez Fonseca, Luis
%A Bugatto González, Fernando
%T Mitochondrial Dysfunction Combined with Elevated CoQ10 Levels Specifically in Placental Cytotrophoblasts Suggests a Role for Mitophagy in Preeclampsia
%D 2026
%@ 2079-7737
%U http://hdl.handle.net/10498/39587
%X Preeclampsia is a severe pregnancy disorder associated with significant morbidity and mortality for both the mother and the baby. The causes underlying the development of preeclampsia remain unknown, but it is well established that the placenta is the organ that triggers the disease and that its mitochondrial metabolism is compromised. This study suggests that the cytotrophoblast is a placental cell type that is particularly affected at the mitochondrial level in preeclampsia. This mitochondrial dysfunction observed in this cell type is accompanied by an increase in coenzyme Q10 levels, which may represent a compensatory response. The data also suggest the activation of a second potential adaptive mechanism in cytotrophoblasts in response to mitochondrial dysfunction—mitophagy. This alteration and putative compensatory response were not observed in syncytiotrophoblasts. These findings highlight the possible specific involvement of the cytotrophoblast during preeclampsia, a cell type characterized by high mitochondrial activity within the placenta. Overall, these observations support the relevance of cytotrophoblast mitochondrial metabolism for future mechanistic studies aimed at better understanding preeclampsia.
%K preeclampsia
%K mitochondria
%K cytotrophoblast
%K mitophagy
%K coenzyme Q10
%~ Universidad de Cádiz