%0 Journal Article 
%A Nebot-Guinot, Aida
%A Liberato González, Andrea
%A Máñez Muñoz, María Ángeles
%A Clares, M. Paz
%A Doménech-Carbó, Antonio
%A Pitarch-Jarque, Javier
%A García Basallote, Manuel
%A García España, Enrique
%T Methylation as an Effective Way to Generate SOD-Activity in Copper Complexes of Scorpiand-Like Azamacrocyclic Receptors
%D 2018
%@ 0020-1693
%U http://hdl.handle.net/10498/39684
%X Methylation of the secondary amine groups of a scorpiand-type ligand consisting of a pyridine spacer connected through methylene groups to a tris(2-aminomethyl) unit with the pendant arm further functionalised with a 3-pyridine unit leads to a ligand whose Cu(II) complex exhibits three-fold enhanced SOD activity with respect to the non-methylated ligand. Potentiometric studies indicate the formation of [CuL]2+ species with a stability three orders of magnitude lower than that formed with the related non-methylated ligand. Kinetic studies indicate that methylation of the secondary nitrogens causes a deceleration of both the complex formation and the acid-induced dissociation of the metal ion. The reduction in stability associated to the poorer -donor ability of the tertiary amino groups shifts the Cu(II)/Cu(I) redox potentials towards more positive values permitting a better cycling between both states needed for the dismutation of superoxide radicals.
%K SOD activity
%K Kinetics
%K Copper complexes
%K Scorpiand-like azamacrocycles
%~ Universidad de Cádiz